[PDF] Pharmaceutical process development : current chemical and engineering challenges A John Blacker; Mike T Williams

Content: Foreword; Preface; Introduction; Process Research and Development in the Pharmaceutical Industry: Origins, Evolution and Progress; Active Pharmaceutical Ingredients: Structure and Impact on Synthesis; Rapid Early Development of Potential Drug Candidates; Route Design and Selection The Importance of Green Chemistry in Process Research & Development; Kinetic Approaches for Faster and Efficient Process Development; The Design of Safe Chemical Reactions – It’s No Accident; Physicochemical Data Requirements for the Design of Fine Chemical Processes – Acquisition and Application; Liquid-Liquid Extraction for Process Development in the Pharmaceutical Industry; Development Enabling Technologies; The Analytical Interface and the Impact on Pharmaceutical Process Development; Materials Science – Solid Form Design and Crystallisation Process Development; Technology Transfer of API; Future Trends and Challenges