{pdf} BetaSys: Systems Biology of Regulated Exocytosis in Pancreatic ?-Cells Flemming Pociot (auth.), Bernhelm Boo?-Bavnbek, Beate Kl?sgen, Jesper Larsen, Flemming Pociot, Erik Renstr?m (eds.)

The insulin secreting ?-cell is one of the most specialized cell types with diverse and multi-functional components (genes, gene products, organelles and metabolites) and a multitude of regulatory strategies in response to internal and environmental signals. This book looks at the technological advances that make simultaneous detection of thousands of biological variables possible; at a substantial variety of mathematical models and numerical simulations that aim to explain major aspects of the ?-cell function; and at the challenge to formulate a comprehensive and robust model of the main networks of the underlying biochemical and physical processes for diagnostic and therapeutic use.