[PDF] The Chemistry and pharmacology of Taxol? and its derivatives Vittorio Farina

The book opens with a review of the naturally occurring taxoids, a cha pter which is not a comprehensive list of all taxoids isolated to date , but attempts a systematic approact to describing the different class es of taxoids, with particular reference to all skeletal types and the various functionality patterns. Biosynthetic studies are also discuss ed, as well as some of the basic chemistry and common functionalities of taxoidic skeleton. Structural identification of taxoids, mostly by spectroscopic means; the formulation of taxanes; the metabolism and ph armacokinetics of Taxol+ are also discussed, as are the chemistry of t axanes in relation to SAR studies; SAR aspects of the phenylisoserine side chain; and the mode of action of the taxanes and the mechanisms o f resistance.