[PDF] Click Chemistry in Glycoscience: New Developments and Strategies

Lays the foundation for new methods and applications of carbohydrate click chemistry

Introduced by K. Barry Sharpless of The Scripps Research Institute in 2001, click chemistry mimics nature, giving researchers the tools needed to generate new substances quickly and reliably by joining small units together. With contributions from more than thirty pioneering researchers in the field, this text explores the many promising applications of click chemistry in glycoscience. Readers will learn both the basic concepts of carbohydrate click chemistry as well as its many biomedical applications, including synthetic antigens, analogs of cell-surface receptors, immobilized enzymes, targeted drug delivery systems, and multivalent cancer vaccines.
Click Chemistry in Glycoscience examines a broad range of methodologies and strategies that have emerged from this rapidly evolving field. Each chapter describes new approaches, ideas, consequences, and applications resulting from the introduction of click processes. Divided into four sections, the book covers: Click chemistry strategies and decouplingThio-click chemistry of carbohydratesCarbohydrate click chemistry for novel synthetic targetsCarbohydrate click chemistry in biomedical sciences
Thoroughly researched, the book reflects the most recent findings published in the literature. Diagrams and figures throughout the book enable readers to more easily grasp complex concepts and reaction processes. At the end of each chapter, references lead to the primary literature for further investigation of individual topics.
The application of click chemistry to carbohydrates has tremendous implications for research. With this book as their guide, researchers have a solid foundation from which they can develop new methods and applications of carbohydrate click chemistry, including new carbohydrate-based therapeutics.Content:
Chapter 1 Paradigm and Advantage of Carbohydrate Click Chemistry Strategy for Future Decoupling (pages 1?30): Roman Bielski and Zbigniew J. Witczak
Chapter 2 Thio?Click Chemistry in Glycoscience: Overview and Perspectives (pages 31?43): Zbigniew J. Witczak
Chapter 3 Free?Radical Thiol?Ene and Thiol?Yne Couplings as Click Processes for Glycoconjugation (pages 45?75): Alessandro Dondoni and Alberto Marra
Chapter 4 The Development and Application of Clickable Lipid Analogs for Elucidating and Harnessing Lipid Functions (pages 77?105): Michael D. Best
Chapter 5 Clicking Sugars onto Sugars: Oligosaccharide Analogs and Glycoclusters on Carbohydrate Scaffolds (pages 107?142): Maria Laura Uhrig and Jose Kovensky
Chapter 6 Click Multivalent Glycomaterials: Glycoclusters, Glycodendrimers, Glycopolymers, Hybrid Glycomaterials, and Glycosurfaces (pages 143?182): Carmen Ortiz Mellet, Alejandro Mendez?Ardoy and Jose Manuel Garcia Fernandez
Chapter 7 Toward Imaging Glycotools by Click Coupling (pages 183?210): Yves Chapleur, Christine Vala, Francoise Chretien and Sandrine Lamande?Langle
Chapter 8 Bioorthogonal Reactions for Labeling Glycoconjugates (pages 211?233): Frederic Friscourt and Geert?Jan Boons
Chapter 9 ?Sweet? Sucrose Macrocycles via a ?Click Chemistry? Route (pages 235?250): Mykhaylo A. Potopnyk and Slawomir Jarosz
Chapter 10 Neoglycoprotein Synthesis Using the Copper?Catalyzed Azide?Alkyne Click Reaction and Native Chemical Ligation (pages 251?270): Joanna M. Wojnar, Dong Jun Lee, Clive W. Evans, Kalyaneswar Mandal, Stephen B. H. Kent and Margaret A. Brimble
Chapter 11 Biomedical Applications of ?Click??Modified Cyclodextrins (pages 271?292): Zhenshan Jia, Rakesh K. Singh and Dong Wang
Chapter 12 Triazolyl Glycoconjugates in Medicinal Chemistry (pages 293?323): Rama Pati Tripathi, Pratibha Dwivedi, Anindra Sharma, Divya Kushwaha and Vinod Kumar Tiwari
Chapter 13 Click Chemistry Applied to Carbohydrate?Based Drug Discovery (pages 325?357): Vanessa Leiria Campo and Ivone Carvalho