[PDF] Drug Targeting: Organ-Specific Strategies, Volume 12 Raimund Mannhold, Hugo Kubinyi, Hendrik Timmerman(eds.)

How are medicines transported intact through the body to their specific target sites without triggering side effects? The answer is “Drug Targeting”.
This thoroughly application-oriented book gives comprehensive answers to this and many other questions that confront scientists daily in chemical, pharmaceutical and medical research. A concise overview of the most important basic theories, modern forms of therapy and molecular biological tools, it represents a comprehensible introduction to the topic. The book then goes on to deal with strategies for target applications, divided according to target site, for example brain, lungs, liver, blood vessels and tumor cells. The third part is devoted to special, modern techniques, from phage display methods, via the use of tissue slices right up to pharmacokinetic modeling. Throughout, the focus remains on the practical aspect and successful application of the method in question, although a glance at what the future holds is also included. A volume that every pharmaceutically oriented research group should own.

Content:
Chapter 1 Drug Targeting: Basic Concepts and Novel Advances (pages 1?22): Grietje Molema
Chapter 2 Brain?Specific Drug Targeting Strategies (pages 23?52): Ulrich Bickel, Young?Sook Kang and Jorg Huwyler
Chapter 3 Pulmonary Drug Delivery: Delivery to and Through the Lung (pages 53?87): Anne H. de Boer, Grietje Molema and Henderik W. Frijlink
Chapter 4 Cell Specific Delivery of Anti?Inflammatory Drugs to Hepatic Endothelial and Kupffer Cells for the Treatment of Inflammatory Liver Diseases (pages 89?120): Barbro N. Melgert, Leonie Beljaars, Dirk K. F. Meijer and Klaas Poelstra
Chapter 5 Delivery of Drugs and Antisense Oligonucleotides to the Proximal Tubular Cell of the Kidney Using Macromolecular and Pro?drug Approaches (pages 121?155): Marijke Haas, Yukio Kato, R. Folgert G. Haverdings, Frits Moolenaar, Kokichi Suzuki, Dick de Zeeuw, Yuichi Sugiyama and Dirk K. F. Meijer
Chapter 6 A Practical Approach in the Design of Colon?specific Drug Delivery Systems (pages 157?170): Claudia S. Leopold
Chapter 7 Vascular Endothelium in Inflamed Tissue as a Target for Site Selective Delivery of Drugs (pages 171?197): Maaike Everts, Astrid J. Schraa, Lou F. M. H. de Leij, Dirk K. F. Meijer and Grietje Molema
Chapter 8 Strategies for Specific Drug Targeting to Tumour Cells (pages 199?231): Jos G. W. Kosterink, Wijnand Helfrich and Lou F. M. H. de Leij
Chapter 9 Tumour Vasculature Targeting (pages 233?254): Daisy W. J. van der Schaft, S. Ramakrishnan, Grietje Molema and Arjan W. Griffioen
Chapter 10 Phage Display Technology for Target Discovery in Drug Delivery Research (pages 255?273): Ricardo Mutuberria, Jan?Willem Arends, Arjan W. Griffioen and Hennie R. Hoogenboom
Chapter 11 Development of Proteinaceous Drug Targeting Constructs Using Chemical and Recombinant DNA Approaches (pages 275?308): Robbert J. Kok, Sigridur A. Asgeirsdottir and Willem R. Verweij
Chapter 12 Use of Human Tissue Slices in Drug Targeting Research (pages 309?331): Peter Olinga and Geny M. M. Groothuis
Chapter 13 Pharmacokinetic/Pharmacodynamic Modelling in Drug Targeting (pages 333?370): Johannes H. Proost
Chapter 14 Drug Targeting Strategy: Scrutinize the Concepts Before Screening the Constructs (pages 371?375): Dirk K. F. Meijer