[PDF] Dynamic Combinatorial Chemistry: In Drug Discovery, Bioorganic Chemistry, and Materials Science

Effective techniques for applying Dynamic Combinatorial Chemistry
In a relatively short period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a few isolated labs to a broad conceptual framework with applications to an exceptional range of problems in molecular recognition, lead compound identification, catalyst design, nanotechnology, polymer science, and others. Bringing together a group of respected experts, this overview explains how chemists can apply DCC and fragment-based library methods to lead generation for drug discovery and molecular recognition in bioorganic chemistry and materials science.
Chapters cover:
Basic theory
Approaches to binding in proteins and nucleic acids
Molecular recognition
Self-sorting
Catalyst discovery
Materials discovery
Analytical chemistry challenges
A comprehensive, single-source reference about DCC methods and applications including aspects of fragment-based drug discovery, this is a core reference that will spark the development of new solutions and strategies for chemists building structure libraries and designing compounds and materials.Content:
Chapter 1 Dynamic Combinatorial Chemistry: An Introduction (pages 1?42): Benjamin L. Miller
Chapter 2 Protein?Directed Dynamic Combinatorial Chemistry (pages 43?82): Michael F. Greaney and Venugopal T. Bhat
Chapter 3 Nucleic Acid?Targeted Dynamic Combinatorial Chemistry (pages 83?117): Peter C. Gareiss and Benjamin L. Miller
Chapter 4 Complex Self?Sorting Systems (pages 118?154): Soumyadip Ghosh and Lyle Isaacs
Chapter 5 Chiral Selection in DCC (pages 155?168): Jennifer J. Becker and Michel R. Gagne
Chapter 6 Dynamic Combinatorial Resolution (pages 169?200): Marcus Angelin, Rikard Larsson, Pornrapee Vongvilai, Morakot Sakulsombat and Olof Ramstrom
Chapter 7 Dynamic Combinatorial Chemistry and Mass Spectrometry: A Combined Strategy for High Performance Lead Discovery (pages 201?228): Sally?Ann Poulsen and Hoan Vu
Chapter 8 Dynamic Combinatorial Methods in Materials Science (pages 229?260): Takeshi Maeda, Hideyuki Otsuka and Atsushi Takahara