[PDF] Neurodegeneration : metallostasis and proteostasis Danilo Milardi; E Rizzarelli

This book covers the latest developments in the understanding the pathogenesis of neurodegenerative diseases. Content: Chemical evolution, brain and metallomics; Chemistry and biology of proteostasis; Environmental factors affecting cellular proteostasis; Neurodegeneration and cell membranes; The role of Metals in the intracellular clearance of amyloids; Speciation, coordination sites and metal binding affinities of proteins related to neurodegeneration; Copper, Zinc and trophic factors in neurodegeneration; Metals as catalysts of ROS production in neurodegeneration; Metal hypothesis of Alzheimer disease; Copper supply and metal homeostasis in AD; The role of iron in neurodegeneration; Aluminium in neurodegenerative diseases; Zinc trafficking in the AD brain; The role of metal ions in the pathogenesis of Parkinson’s disease; Metals in ALS pathology; Metals and prion diseases Abstract: This book covers the latest developments in the understanding the pathogenesis of neurodegenerative diseases. Read more…