[PDF] Therapeutic proteins : strategies to modulate their plasma half-lives Roland Kontermann

Content: Front Matter —
General Information. Half-Life Modulating Strategies : An Introduction / Roland E Kontermann —
Pharmacokinetics and Half-Life of Protein Therapeutics / Bernd Meibohm —
Half-Life Extension through Chemical and Post-Translational Modifications. Half-Life Extension through PEGylation / Simona Jev?evar, Menci Kunstelj —
Half-Life Extension of Therapeutic Proteins via Genetic Fusion to Recombinant PEG Mimetics / Uli Binder, Arne Skerra —
Half-Life Extension through -Glycosylation / Fuad Fares —
Polysialic Acid and Polysialylation to Modulate Antibody Pharmacokinetics / Antony Constantinou, Chen Chen, Mahendra P Deonarain —
Half-Life Extension through HESylation? / Thomas Hey, Helmut Knoller, Peter Vorstheim —
Half-Life Modulation Involving Recycling by the Neonatal Fc Receptor. The Biology of the Neonatal Fc Receptor (FcRn) / Jonghan Kim —
Half-Life Extension by Fusion to the Fc Region / Jalal A Jazayeri, Graeme J Carroll —
Monomeric Fc Fusion Technology: An Approach to Create Long-Lasting Clotting Factors / Jennifer A Dumont, Xiaomei Jin, Robert T Peters, Alvin Luk, Glenn F Pierce, Alan J Bitonti —
The Diverse Roles of FcRn: Implications for Antibody Engineering / E Sally Ward, Raimund J Ober —
Half-Life Extension by Fusion to Recombinant Albumin / Hubert J Metzner, Thomas Weimer, Stefan Schulte —
AlbudAb? Technology Platform?Versatile Albumin Binding Domains for the Development of Therapeutics with Tunable Half-Lives / Christopher Herring, Oliver Schon —
Half-Life Extension by Binding to Albumin through an Albumin Binding Domain / Fredrik Y Frejd —
Half-Life Extension by Binding to Albumin through Small Molecules / Sabrina Trussel, Joerg Scheuermann, Dario Neri —
Half-Life Extension with Pharmaceutical Formulations. Half-Life Extension with Pharmaceutical Formulations: Liposomes / Astrid Hartung, Gerd Bendas —
Half-Life Extension with Pharmaceutical Formulations: Nanoparticles by the Miniemulsion Process / Katharina Landfester, Anna Musyanovych, Volker Mail?nder —
Index.